SCOPe 2.07: Domain d4qwrl_: 4qwr L:

Lineage for d4qwrl_ (4qwr L:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.4: Proteasome subunits [56251] (4 proteins)

6. Protein Proteasome beta subunit (catalytic) [56252] (7 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (202 PDB entries)
   The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)

8. Domain d4qwrl_: 4qwr L: [308939]
   Other proteins in same PDB: d4qwrb_, d4qwrc_, d4qwrd_, d4qwre_, d4qwrf_, d4qwrg_, d4qwrh_, d4qwrk_, d4qwrm_, d4qwrp_, d4qwrq_, d4qwrr_, d4qwrs_, d4qwrt_, d4qwru_, d4qwrv_, d4qwry_
   automated match to d1rypm_
   complexed with 3bv, cl, mes, mg; mutant

Details for d4qwrl_

PDB Entry: 4qwr, 2.9 Å

PDB Description: yCP beta5-C52F mutant in complex with carfilzomib

PDB Compounds: (L:) Proteasome subunit beta type-6

SCOPe Domain Sequences for d4qwrl_:

Sequence; same for both SEQRES and ATOM records:

>d4qwrl_ d.153.1.4 (L:) Proteasome beta subunit (catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
qfnpygdnggtilgiagedfavlagdtrnitdysinsryepkvfdcgdnivmsangfaad
gdalvkrfknsvkwyhfdhndkklsinsaarniqhllygkrffpyyvhtiiagldedgkg
avysfdpvgsyereqcraggaaaslimpfldnqvnfknqyepgtngkvkkplkylsveev
iklvrdsftsaterhiqvgdgleilivtkdgvrkefyelkrd

Timeline for d4qwrl_:

• d4qwrl_ first appeared in SCOPe 2.06
  
• d4qwrl_ appears in the current release, SCOPe 2.08