SCOPe 2.07: Domain d4qwkm_: 4qwk M:

Lineage for d4qwkm_ (4qwk M:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.4: Proteasome subunits [56251] (4 proteins)

6. Protein automated matches [190144] (14 species)
   not a true protein

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189752] (203 PDB entries)

8. Domain d4qwkm_: 4qwk M: [308892]
   Other proteins in same PDB: d4qwka_, d4qwkc_, d4qwkd_, d4qwke_, d4qwkg_, d4qwki_, d4qwkj_, d4qwkk_, d4qwkl_, d4qwkn_, d4qwko_, d4qwkq_, d4qwkr_, d4qwks_, d4qwku_, d4qwkw_, d4qwkx_, d4qwky_, d4qwkz_
   automated match to d4j70m_
   complexed with 3bv, cl, mes, mg; mutant

Details for d4qwkm_

PDB Entry: 4qwk, 2.8 Å

PDB Description: yCP beta5-A49T-A50V-double mutant in complex with carfilzomib

PDB Compounds: (M:) Proteasome subunit beta type-7

SCOPe Domain Sequences for d4qwkm_:

Sequence; same for both SEQRES and ATOM records:

>d4qwkm_ d.153.1.4 (M:) automated matches {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 559292]}
tqqpivtgtsvismkydngviiaadnlgsygsllrfngverlipvgdntvvgisgdisdm
qhierllkdlvtenaydnpladaeealepsyifeylatvmyqrrskmnplwnaiivagvq
sngdqflryvnllgvtyssptlatgfgahmanpllrkvvdresdipkttvqvaeeaivna
mrvlyyrdarssrnfslaiidkntgltfkknlqvenmkwdfakdikgygt

Timeline for d4qwkm_:

• d4qwkm_ first appeared in SCOPe 2.06
  
• d4qwkm_ appears in the current release, SCOPe 2.08