SCOPe 2.07: Domain d4qwga_: 4qwg A:

Lineage for d4qwga_ (4qwg A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.4: Proteasome subunits [56251] (4 proteins)

6. Protein Proteasome beta subunit (catalytic) [56252] (7 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (202 PDB entries)
   The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)

8. Domain d4qwga_: 4qwg A: [308809]
   Other proteins in same PDB: d4qwgb_, d4qwgc_, d4qwgd_, d4qwge_, d4qwgf_, d4qwgg_, d4qwgh_, d4qwgk_, d4qwgm_, d4qwgp_, d4qwgq_, d4qwgr_, d4qwgs_, d4qwgt_, d4qwgu_, d4qwgv_, d4qwgy_
   automated match to d1jd2v_
   complexed with 3bv, cl, mes, mg; mutant

Details for d4qwga_

PDB Entry: 4qwg, 2.6 Å

PDB Description: yCP beta5-A49V mutant in complex with carfilzomib

PDB Compounds: (A:) Proteasome subunit alpha type-2

SCOPe Domain Sequences for d4qwga_:

Sequence; same for both SEQRES and ATOM records:

>d4qwga_ d.153.1.4 (A:) Proteasome beta subunit (catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mtdrysfslttfspsgklgqidyaltavkqgvtslgikatngvviatekksssplamset
lskvslltpdigavysgmgpdyrvlvdksrkvahtsykriygeypptkllvsevakimqe
atqsggvrpfgvslliaghdefngfslyqvdpsgsyfpwkataigkgsvaaktflekrwn
deleledaihialltlkesvegefngdtielaiigdenpdllgytgiptdkgprfrklts
qeindrleal

Timeline for d4qwga_:

• d4qwga_ first appeared in SCOPe 2.06
  
• d4qwga_ appears in the current release, SCOPe 2.08