SCOPe 2.07: Domain d4qvya_: 4qvy A:

Lineage for d4qvya_ (4qvy A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
   4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing

4. Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families)
   N-terminal residue provides two catalytic groups, nucleophile and proton donor

5. Family d.153.1.4: Proteasome subunits [56251] (4 proteins)

6. Protein Proteasome beta subunit (catalytic) [56252] (7 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (202 PDB entries)
   The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)

8. Domain d4qvya_: 4qvy A: [308593]
   Other proteins in same PDB: d4qvyb_, d4qvyc_, d4qvyd_, d4qvye_, d4qvyf_, d4qvyg_, d4qvyh_, d4qvyk_, d4qvym_, d4qvyp_, d4qvyq_, d4qvyr_, d4qvys_, d4qvyt_, d4qvyu_, d4qvyv_, d4qvyy_
   automated match to d1jd2v_
   complexed with bo2, cl, mg; mutant

Details for d4qvya_

PDB Entry: 4qvy, 2.51 Å

PDB Description: yCP beta5-A49T-mutant in complex with bortezomib

PDB Compounds: (A:) Proteasome subunit alpha type-2

SCOPe Domain Sequences for d4qvya_:

Sequence; same for both SEQRES and ATOM records:

>d4qvya_ d.153.1.4 (A:) Proteasome beta subunit (catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mtdrysfslttfspsgklgqidyaltavkqgvtslgikatngvviatekksssplamset
lskvslltpdigavysgmgpdyrvlvdksrkvahtsykriygeypptkllvsevakimqe
atqsggvrpfgvslliaghdefngfslyqvdpsgsyfpwkataigkgsvaaktflekrwn
deleledaihialltlkesvegefngdtielaiigdenpdllgytgiptdkgprfrklts
qeindrleal

Timeline for d4qvya_:

• d4qvya_ first appeared in SCOPe 2.06
  
• d4qvya_ appears in the current release, SCOPe 2.08