SCOPe 2.07: Domain d4q1ab_: 4q1a B:

Lineage for d4q1ab_ (4q1a B:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Deoxycytidine kinase [89657] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89658] (45 PDB entries)

8. Domain d4q1ab_: 4q1a B: [308059]
   automated match to d4jlnb_
   complexed with 2xz, udp; mutant

Details for d4q1ab_

PDB Entry: 4q1a, 1.9 Å

PDB Description: Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 6 {2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethanol}

PDB Compounds: (B:) Deoxycytidine kinase

SCOPe Domain Sequences for d4q1ab_:

Sequence, based on SEQRES records:

>d4q1ab_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmeqkngg
nvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifas
nlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqg
ipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflst
l

Sequence, based on observed residues (ATOM records):

>d4q1ab_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnltmeqknggnvlqmmyekp
erwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmne
tewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklh
ykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

Timeline for d4q1ab_:

• d4q1ab_ first appeared in SCOPe 2.06
  
• d4q1ab_ appears in the current release, SCOPe 2.08