SCOPe 2.06: Domain d4omea1: 4ome A:55-117,A:351-593

Lineage for d4omea1 (4ome A:55-117,A:351-593)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

5. Family c.56.5.5: FolH catalytic domain-like [53210] (2 proteins)

6. Protein Glutamate carboxypeptidase II FOLH1 [142522] (1 species)
   Folate hydrolase 1, FolH homologue

7. Species Human (Homo sapiens) [TaxId:9606] [142523] (24 PDB entries)
   Uniprot Q04609 57-117,351-593

8. Domain d4omea1: 4ome A:55-117,A:351-593 [307910]
   Other proteins in same PDB: d4omea2, d4omea3
   automated match to d2c6ca3
   complexed with ca, cl, dgq, nag, zn

Details for d4omea1

PDB Entry: 4ome, 1.79 Å

PDB Description: x-ray structure of human glutamate carboxypeptidase ii in complex with dccbl, a urea based inhibitor with distal carborane moiety

PDB Compounds: (A:) glutamate carboxypeptidase 2

SCOPe Domain Sequences for d4omea1:

Sequence, based on SEQRES records:

>d4omea1 c.56.5.5 (A:55-117,A:351-593) Glutamate carboxypeptidase II FOLH1 {Human (Homo sapiens) [TaxId: 9606]}
khnmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahyd
vllXevtriynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlk
kegwrprrtilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlrvdc
tplmyslvhnltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffq
rlgiasgrarytknwetnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfe
lansivl

Sequence, based on observed residues (ATOM records):

>d4omea1 c.56.5.5 (A:55-117,A:351-593) Glutamate carboxypeptidase II FOLH1 {Human (Homo sapiens) [TaxId: 9606]}
khnmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahyd
vllXevtriynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlk
kegwrprrtilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlrvdc
tplmyslvhnltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffq
rlgiasgrarytknwetfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfela
nsivl

Timeline for d4omea1:

• d4omea1 is new in SCOPe 2.06-stable
  
• d4omea1 appears in SCOPe 2.07
  
• d4omea1 appears in the current release, SCOPe 2.08