SCOPe 2.06: Domain d4gq4a2: 4gq4 A:231-588

Lineage for d4gq4a2 (4gq4 A:231-588)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (25 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.8: TPR-like [48452] (9 families)

5. Family a.118.8.1: Tetratricopeptide repeat (TPR) [48453] (20 proteins)
   this is a repeat family; one repeat unit is 1zb1 A:166-231 found in domain

6. Protein Menin C-terminal domain [310725] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [310974] (23 PDB entries)

8. Domain d4gq4a2: 4gq4 A:231-588 [307465]
   Other proteins in same PDB: d4gq4a1
   automated match to d3u85a2
   complexed with 0rt, dms, epe, pe4, so4, unx

Details for d4gq4a2

PDB Entry: 4gq4, 1.27 Å

PDB Description: Human menin with bound inhibitor MI-2-2

PDB Compounds: (A:) Menin

SCOPe Domain Sequences for d4gq4a2:

Sequence, based on SEQRES records:

>d4gq4a2 a.118.8.1 (A:231-588) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsvpapaaspppegpvltfqsekmk
gmkellvatkinssaiklqltaqsqvqmk

Sequence, based on observed residues (ATOM records):

>d4gq4a2 a.118.8.1 (A:231-588) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsvpgpvltfqsekmkgmkellvat
kinssaiklqltaqsqvqmk

Timeline for d4gq4a2:

• d4gq4a2 is new in SCOPe 2.06-stable
  
• d4gq4a2 appears in SCOPe 2.07
  
• d4gq4a2 appears in the current release, SCOPe 2.08