SCOPe 2.08: Domain d4gq3a2: 4gq3 A:231-588

Lineage for d4gq3a2 (4gq3 A:231-588)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.8: TPR-like [48452] (11 families)

5. Family a.118.8.1: Tetratricopeptide repeat (TPR) [48453] (21 proteins)
   this is a repeat family; one repeat unit is 1zb1 A:166-231 found in domain

6. Protein Menin C-terminal domain [310725] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [310974] (33 PDB entries)

8. Domain d4gq3a2: 4gq3 A:231-588 [307463]
   Other proteins in same PDB: d4gq3a1
   automated match to d3u85a2
   complexed with 0ro, peg, so4, unx
   has additional insertions and/or extensions that are not grouped together

Details for d4gq3a2

PDB Entry: 4gq3, 1.56 Å

PDB Description: Human menin with bound inhibitor MI-2

PDB Compounds: (A:) Menin

SCOPe Domain Sequences for d4gq3a2:

Sequence, based on SEQRES records:

>d4gq3a2 a.118.8.1 (A:231-588) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsvpapaaspppegpvltfqsekmk
gmkellvatkinssaiklqltaqsqvqmk

Sequence, based on observed residues (ATOM records):

>d4gq3a2 a.118.8.1 (A:231-588) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsgpvltfqsekmkgmkellvatki
nssaiklqltaqsqvqmk

Timeline for d4gq3a2:

• d4gq3a2 first appeared in SCOPe 2.06
  
• d4gq3a2 appears in SCOPe 2.07