SCOPe 2.08: Domain d4ei3a3: 4ei3 A:578-859

Lineage for d4ei3a3 (4ei3 A:578-859)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (18 families)
   consists of one domain of this fold

5. Family c.55.3.15: PIWI domain C-terminal [310608] (4 proteins)
   PubMed 15565169 notes that both halves of PIWI are usually a single evolutionary unit; however, fragments have been characterized separately. The N-terminal half is (c.44.3.1)

6. Protein Argonaute-2 [310719] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [310965] (4 PDB entries)

8. Domain d4ei3a3: 4ei3 A:578-859 [307302]
   Other proteins in same PDB: d4ei3a1, d4ei3a2
   automated match to d4olaa3
   protein/RNA complex; complexed with trp

Details for d4ei3a3

PDB Entry: 4ei3, 2.89 Å

PDB Description: Crystal Structure of Human Argonaute2

PDB Compounds: (A:) Protein argonaute-2

SCOPe Domain Sequences for d4ei3a3:

Sequence, based on SEQRES records:

>d4ei3a3 c.55.3.15 (A:578-859) Argonaute-2 {Human (Homo sapiens) [TaxId: 9606]}
llpqgrppvfqqpviflgadvthppagdgkkpsiaavvgsmdahpnrycatvrvqqhrqe
iiqdlaamvrelliqfykstrfkptriifyrdgvsegqfqqvlhhellaireaciklekd
yqpgitfivvqkrhhtrlfctdknervgksgnipagttvdtkithptefdfylcshagiq
gtsrpshyhvlwddnrfssdelqiltyqlchtyvrctrsvsipapayyahlvafraryhl
vdkehdsaegshtsgqsngrdhqalakavqvhqdtlrtmyfa

Sequence, based on observed residues (ATOM records):

>d4ei3a3 c.55.3.15 (A:578-859) Argonaute-2 {Human (Homo sapiens) [TaxId: 9606]}
llpqgrppvfqqpviflgadvthppkkpsiaavvgsmdahpnrycatvrvqqhrqeiiqd
laamvrelliqfykstrfkptriifyrdgvsegqfqqvlhhellaireaciklekdyqpg
itfivvqkrhhtrlfctdknervgksgnipagttvdtkithptefdfylcshagiqgtsr
pshyhvlwddnrfssdelqiltyqlchtyvrctrsvsipapayyahlvafraryhlvqal
akavqvhqdtlrtmyfa

Timeline for d4ei3a3:

• d4ei3a3 first appeared in SCOPe 2.06
  
• d4ei3a3 appears in SCOPe 2.07