SCOPe 2.08: Domain d4da5a_: 4da5 A:

Lineage for d4da5a_ (4da5 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.8: Choline kinase [90040] (2 proteins)
   Pfam PF02958

6. Protein Choline kinase [90041] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [311002] (13 PDB entries)

8. Domain d4da5a_: 4da5 A: [307247]
   automated match to d2i7qa_
   complexed with 0h7, so4

Details for d4da5a_

PDB Entry: 4da5, 2.4 Å

PDB Description: choline kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology

PDB Compounds: (A:) choline kinase alpha

SCOPe Domain Sequences for d4da5a_:

Sequence, based on SEQRES records:

>d4da5a_ d.144.1.8 (A:) Choline kinase {Human (Homo sapiens) [TaxId: 9606]}
eqpeprtrrraylwckeflpgawrglredefhisvirgglsnmlfqcslpdttatlgdep
rkvllrlygailqmrscnkegseqaqkenefqgaeamvlesvmfailaerslgpklygif
pqgrleqfipsrrldteelslpdisaeiaekmatfhgmkmpfnkepkwlfgtmekylkev
lrikfteesrikklhkllsynlplelenlrsllestpspvvfchndcqegnilllegren
sekqklmlidfeyssynyrgfdignhfcewmydysyekypffranirkyptkkqqlhfis
sylpafqndfenlsteeksiikeemllevnrfalashflwglwsivqakissiefgymdy
aqarfdayfhqkrklgv

Sequence, based on observed residues (ATOM records):

>d4da5a_ d.144.1.8 (A:) Choline kinase {Human (Homo sapiens) [TaxId: 9606]}
eqpeprtrrraylwckeflpgawrglredefhisvirgglsnmlfqcslpdttatlgdep
rkvllrlyaeamvlesvmfailaerslgpklygifpqgrleqfipsrrldteelslpdis
aeiaekmatfhgmkmpfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlple
lenlrsllestpspvvfchndcqegnilllegrensekqklmlidfeyssynyrgfdign
hfcewmydysyekypffranirkyptkkqqlhfissylpafqndfenlsteeksiikeem
llevnrfalashflwglwsivqakissiefgymdyaqarfdayfhqkrklgv

Timeline for d4da5a_:

• d4da5a_ first appeared in SCOPe 2.06
  
• d4da5a_ appears in SCOPe 2.07