SCOPe 2.08: Domain d3wzka_: 3wzk A:

Lineage for d3wzka_ (3wzk A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d3wzka_: 3wzk A: [306939]
   automated match to d5d9ka_
   complexed with cl, o23

Details for d3wzka_

PDB Entry: 3wzk, 2.3 Å

PDB Description: crystal structure of human mps1 catalytic domain in complex with n- cyclopropyl-4-(8-((thiophen-2-ylmethyl)amino)imidazo[1,2-a]pyrazin-3- yl)benzamide

PDB Compounds: (A:) Dual specificity protein kinase TTK

SCOPe Domain Sequences for d3wzka_:

Sequence, based on SEQRES records:

>d3wzka_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppeai
kdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheie
fpdipekdlqdvlkcclkrdpkqrisipellahpyvqiq

Sequence, based on observed residues (ATOM records):

>d3wzka_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpdgtvnymppeaikdmsispksd
vwslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdp
kqrisipellahpyvqiq

Timeline for d3wzka_:

• d3wzka_ first appeared in SCOPe 2.06
  
• d3wzka_ appears in SCOPe 2.07