SCOPe 2.08: Domain d3re2a2: 3re2 A:206-475

Lineage for d3re2a2 (3re2 A:206-475)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.8: TPR-like [48452] (11 families)

5. Family a.118.8.1: Tetratricopeptide repeat (TPR) [48453] (21 proteins)
   this is a repeat family; one repeat unit is 1zb1 A:166-231 found in domain

6. Protein Menin C-terminal domain [310725] (2 species)

7. Species Nematostella vectensis [TaxId:45351] [310973] (1 PDB entry)

8. Domain d3re2a2: 3re2 A:206-475 [306446]
   Other proteins in same PDB: d3re2a1
   complexed with gol
   has additional insertions and/or extensions that are not grouped together

Details for d3re2a2

PDB Entry: 3re2, 1.95 Å

PDB Description: Crystal structure of menin reveals the binding site for Mixed Lineage Leukemia (MLL) protein

PDB Compounds: (A:) Predicted protein

SCOPe Domain Sequences for d3re2a2:

Sequence, based on SEQRES records:

>d3re2a2 a.118.8.1 (A:206-475) Menin C-terminal domain {Nematostella vectensis [TaxId: 45351]}
trhmevasiissinpninhttdsiqlsqlqqellwllydmghiktypmaianlgdleeis
ptpgrppaeelfkeaitvakreysdhhiypytylggyyyrkkkyyeaiaswvdagyvagk
ynyskddeemykefheiandlipnilkdavakadpsgtgstnltsdpkffalvlqfydgi
clweegsptpvlhadwakklvqsigkfapecrsafnantdtlslrsakmremknlittsg
klntsamklqlta

Sequence, based on observed residues (ATOM records):

>d3re2a2 a.118.8.1 (A:206-475) Menin C-terminal domain {Nematostella vectensis [TaxId: 45351]}
trhmevasiissinpninhttdsiqlsqlqqellwllydmghiktypmaianlgdleeis
ptpgrppaeelfkeaitvakreysdhhiypytylggyyyrkkkyyeaiaswvdagyvagk
ynyskddeemykefheiandlipnilkdavakanltsdpkffalvlqfydgiclweegsp
tpvlhadwakklvqsigkfapecrsafnantdtlslrsakmremknlitntsamklqlta

Timeline for d3re2a2:

• d3re2a2 first appeared in SCOPe 2.06
  
• d3re2a2 appears in SCOPe 2.07