SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for d3qx8c_ (3qx8 C:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2116033Fold c.44: Phosphotyrosine protein phosphatases I-like [52787] (3 superfamilies)
    3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134
  4. 2116195Superfamily c.44.3: PIWI domain N-terminal-like [310581] (2 families) (S)
  5. 2116196Family c.44.3.1: PIWI domain N-terminal [310609] (4 protein domains)
    PubMed 15565169 notes that both halves of PIWI are usually a single evolutionary unit; however, fragments have been characterized separately. The C-terminal half is (c.55.3.10)
  6. 2116210Protein Argonaute-2 [310718] (1 species)
    Pfam PF16487
  7. 2116211Species Human (Homo sapiens) [TaxId:9606] [310964] (12 PDB entries)
  8. 2116235Domain d3qx8c_: 3qx8 C: [306393]
    automated match to d3luha_
    protein/RNA complex; complexed with gtg

Details for d3qx8c_

PDB Entry: 3qx8 (more details), 2.3 Å

PDB Description: Crystal structure of MID domain from hAGO2 in complex with m7GpppG
PDB Compounds: (C:) Protein argonaute-2

SCOPe Domain Sequences for d3qx8c_:

Sequence; same for both SEQRES and ATOM records: (download)

>d3qx8c_ c.44.3.1 (C:) Argonaute-2 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3qx8c_:

Click to download the PDB-style file with coordinates for d3qx8c_.
(The format of our PDB-style files is described here.)

Timeline for d3qx8c_:

  • d3qx8c_ is new in SCOPe 2.06-stable