SCOPe 2.08: Domain d3luhb_: 3luh B:

Lineage for d3luhb_ (3luh B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.44: Phosphotyrosine protein phosphatases I-like [52787] (3 superfamilies)
   3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134

4. Superfamily c.44.3: PIWI domain N-terminal-like [310581] (2 families)

5. Family c.44.3.1: PIWI domain N-terminal [310609] (4 proteins)
   PubMed 15565169 notes that both halves of PIWI are usually a single evolutionary unit; however, fragments have been characterized separately. The C-terminal half is (c.55.3.10)

6. Protein Argonaute-2 [310718] (1 species)
   Pfam PF16487

7. Species Human (Homo sapiens) [TaxId:9606] [310964] (12 PDB entries)

8. Domain d3luhb_: 3luh B: [305880]
   automated match to d3luha_
   protein/RNA complex; complexed with 5gp, po4

Details for d3luhb_

PDB Entry: 3luh, 2 Å

PDB Description: crystal structure of mid domain from hago2 in complex with gmp

PDB Compounds: (B:) Protein argonaute-2

SCOPe Domain Sequences for d3luhb_:

Sequence; same for both SEQRES and ATOM records:

>d3luhb_ c.44.3.1 (B:) Argonaute-2 {Human (Homo sapiens) [TaxId: 9606]}
kqfhtgieikvwaiacfapqrqctevhlksfteqlrkisrdagmpiqgqpcfckyaqgad
svepmfrhlkntyaglqlvvvilpgktpvyaevkrvgdtvlgmatqcvqmknvqrttpqt
lsnlclkinvklg

Timeline for d3luhb_:

• d3luhb_ first appeared in SCOPe 2.06
  
• d3luhb_ appears in SCOPe 2.07