SCOPe 2.07: Domain d3hwva_: 3hwv A:

Lineage for d3hwva_ (3hwv A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.94: Periplasmic binding protein-like II [53849] (1 superfamily)
   consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
   mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest

4. Superfamily c.94.1: Periplasmic binding protein-like II [53850] (4 families)
   Similar in architecture to the superfamily I but partly differs in topology

5. Family c.94.1.2: Transferrin [53888] (4 proteins)
   further duplication: composed of two two-domain lobes

6. Protein Lactoferrin [53889] (6 species)

7. Species Cow (Bos taurus) [TaxId:9913] [53891] (20 PDB entries)

8. Domain d3hwva_: 3hwv A: [305534]
   automated match to d4oqoa_
   complexed with co3, dif, eoh, fe, so4, zn

Details for d3hwva_

PDB Entry: 3hwv, 1.4 Å

PDB Description: Structural Basis of the Prevention of NSAID-Induced Damage of the Gastrointestinal Tract by C-Terminal Half (C-lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-lobe Complexes with Indomethacin, Diclofenac, Aspirin and Ibuprofen

PDB Compounds: (A:) lactotransferrin

SCOPe Domain Sequences for d3hwva_:

Sequence, based on SEQRES records:

>d3hwva_ c.94.1.2 (A:) Lactoferrin {Cow (Bos taurus) [TaxId: 9913]}
ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
ndnteclaklggrptyeeylgteyvtaianlkkcstsplleacaf

Sequence, based on observed residues (ATOM records):

>d3hwva_ c.94.1.2 (A:) Lactoferrin {Cow (Bos taurus) [TaxId: 9913]}
ytrvvwcavgpeeqkkcqqwsqqsgqnvtcatasttddcivlvlkgeadalnldggyiyt
agkcglvpvlaenrksskhssldcvlrptegylavavvkkanegltwnslkdkkschtav
drtagwnipmglivnqtgscafdeffsqscapgadpksrlcalcagddqgldkcvpnske
kyygytgafrclaedvgdvafvkndtvwentngestadwaknlkredfrllcldgtrkpv
teaqschlavapnhavvsrsdraahveqvllhqqalfgkngkncpdkfclfksetknllf
ndnteclaklggrptyeeylgteyvtaianlkkcsleacaf

Timeline for d3hwva_:

• d3hwva_ first appeared in SCOPe 2.06
  
• d3hwva_ appears in the current release, SCOPe 2.08