SCOPe 2.07: Domain d3gxja_: 3gxj A:

Lineage for d3gxja_ (3gxj A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (32 PDB entries)
   Uniprot P36897 200-500 ! Uniprot P36897 201-503

8. Domain d3gxja_: 3gxj A: [305442]
   automated match to d1vjya_
   complexed with 855

Details for d3gxja_

PDB Entry: 3gxj, 1.7 Å

PDB Description: Structure of Alk5 + GW855857

PDB Compounds: (A:) TGF-beta receptor type-1

SCOPe Domain Sequences for d3gxja_:

Sequence, based on SEQRES records:

>d3gxja_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhenil
gfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmei
vgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkryma
pevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsvee
mrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq

Sequence, based on observed residues (ATOM records):

>d3gxja_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhenil
gfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmei
vgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiagtkrymapevld
dsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsveemrkvv
ceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq

Timeline for d3gxja_:

• d3gxja_ first appeared in SCOPe 2.06
  
• d3gxja_ appears in the current release, SCOPe 2.08