SCOPe 2.06: Domain d3g60a4: 3g60 A:372-626

Lineage for d3g60a4 (3g60 A:372-626)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology

6. Protein P-glycoprotein (P-gp) multidrug resistance protein, head domain [310790] (2 species)
   Pfam PF09818

7. Species Mouse (Mus musculus) [TaxId:10090] [311047] (1 PDB entry)

8. Domain d3g60a4: 3g60 A:372-626 [305401]
   Other proteins in same PDB: d3g60a1, d3g60a2
   complexed with 0jz

Details for d3g60a4

PDB Entry: 3g60, 4.4 Å

PDB Description: Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

PDB Compounds: (A:) Multidrug resistance protein 1a

SCOPe Domain Sequences for d3g60a4:

Sequence; same for both SEQRES and ATOM records:

>d3g60a4 c.37.1.12 (A:372-626) P-glycoprotein (P-gp) multidrug resistance protein, head domain {Mouse (Mus musculus) [TaxId: 10090]}
dsfsksghkpdniqgnlefknihfsypsrkevqilkglnlkvksgqtvalvgnsgcgkst
tvqlmqrlydpldgmvsidgqdirtinvrylreiigvvsqepvlfattiaenirygredv
tmdeiekavkeanaydfimklphqfdtlvgergaqlsggqkqriaiaralvrnpkillld
eatsaldteseavvqaaldkaregrttiviahrlstvrnadviagfdggviveqgnhdel
mrekgiyfklvmtqt

Timeline for d3g60a4:

• d3g60a4 is new in SCOPe 2.06-stable
  
• d3g60a4 appears in SCOPe 2.07
  
• d3g60a4 appears in the current release, SCOPe 2.08