SCOPe 2.08: Domain d3g60a3: 3g60 A:1014-1271

Lineage for d3g60a3 (3g60 A:1014-1271)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
   there are two additional subdomains inserted into the central core that has a RecA-like topology
   missing some secondary structures that made up less than one-third of the common domain
   

6. Protein P-glycoprotein (P-gp) multidrug resistance protein, head domain [310790] (2 species)
   Pfam PF09818

7. Species Mouse (Mus musculus) [TaxId:10090] [311047] (1 PDB entry)

8. Domain d3g60a3: 3g60 A:1014-1271 [305400]
   Other proteins in same PDB: d3g60a1, d3g60a2
   complexed with 0jz

Details for d3g60a3

PDB Entry: 3g60, 4.4 Å

PDB Description: Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

PDB Compounds: (A:) Multidrug resistance protein 1a

SCOPe Domain Sequences for d3g60a3:

Sequence; same for both SEQRES and ATOM records:

>d3g60a3 c.37.1.12 (A:1014-1271) P-glycoprotein (P-gp) multidrug resistance protein, head domain {Mouse (Mus musculus) [TaxId: 10090]}
idsystqglkpnmlegnvqfsgvvfnyptrpsipvlqglslevkkgqtlalvgssgcgks
tvvqllerfydpmagsvfldgkeikqlnvqwlraqlgivsqepilfdcsiaeniaygdns
rvvsyeeivraakeanihqfidslpdkyntrvgdkgtqlsggqkqriaiaralvrqphil
lldeatsaldtesekvvqealdkaregrtciviahrlstiqnadlivviqngkvkehgth
qqllaqkgiyfsmvsvqa

Timeline for d3g60a3:

• d3g60a3 first appeared in SCOPe 2.06
  
• d3g60a3 appears in SCOPe 2.07