Lineage for d1xana2 (1xan A:166-290)

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
    core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
  4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families) (S)
  5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (25 proteins)
    duplication: both domains have similar folds and functions
    most members of the family contain common C-terminal alpha+beta domain
  6. Protein Glutathione reductase, middle domain [418943] (3 species)
  7. Species Human (Homo sapiens) [TaxId:9606] [419397] (23 PDB entries)
  8. Domain d1xana2: 1xan A:166-290 [30450]
    Other proteins in same PDB: d1xana1, d1xana3
    complexed with fad, hxp

Details for d1xana2

PDB Entry: 1xan (more details), 2 Å

PDB Description: human glutathione reductase in complex with a xanthene inhibitor
PDB Compounds: (A:) glutathione reductase

SCOPe Domain Sequences for d1xana2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1xana2 c.3.1.5 (A:166-290) Glutathione reductase, middle domain {Human (Homo sapiens) [TaxId: 9606]}
sqipgaslgitsdgffqleelpgrsvivgagyiavemagilsalgsktslmirhdkvlrs
fdsmistncteelenagvevlkfsqvkevkktlsglevsmvtavpgrlpvmtmipdvdcl
lwaig

SCOPe Domain Coordinates for d1xana2 are not available.

Timeline for d1xana2:

View in 3D
Domains from same chain:
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d1xana1, d1xana3