SCOPe 2.08: Domain d1xana1: 1xan A:18-165,A:291-363

Lineage for d1xana1 (1xan A:18-165,A:291-363)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families)

5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (25 proteins)
   duplication: both domains have similar folds and functions
   most members of the family contain common C-terminal alpha+beta domain

6. Protein Glutathione reductase, N- and C-terminal domain [418942] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [419396] (23 PDB entries)

8. Domain d1xana1: 1xan A:18-165,A:291-363 [30449]
   Other proteins in same PDB: d1xana2, d1xana3
   complexed with fad, hxp
   has additional insertions and/or extensions that are not grouped together

Details for d1xana1

PDB Entry: 1xan, 2 Å

PDB Description: human glutathione reductase in complex with a xanthene inhibitor

PDB Compounds: (A:) glutathione reductase

SCOPe Domain Sequences for d1xana1:

Sequence; same for both SEQRES and ATOM records:

>d1xana1 c.3.1.5 (A:18-165,A:291-363) Glutathione reductase, N- and C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
vasydylvigggsgglasarraaelgaraavveshklggtcvnvgcvpkkvmwntavhse
fmhdhadygfpscegkfnwrvikekrdayvsrlnaiyqnnltkshieiirghaaftsdpk
ptievsgkkytaphiliatggmpstpheXrvpntkdlslnklgiqtddkghiivdefqnt
nvkgiyavgdvcgkalltpvaiaagrklahrlfeykedskld

Timeline for d1xana1:

• d1xana1 first appeared (with stable ids) in SCOP 1.55, called d1xan_1
  
• d1xana1 appears in SCOPe 2.07