SCOPe 2.08: Domain d2rioa_: 2rio A:

Lineage for d2rioa_ (2rio A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Endoribonuclease Ire1 [310779] (1 species)
   Pfam PF06478; Includes extra C-terminal alpha-helical KEN domain described in PubMed 18191223

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [311035] (1 PDB entry)

8. Domain d2rioa_: 2rio A: [304460]
   complexed with adp, mg, sr

Details for d2rioa_

PDB Entry: 2rio, 2.4 Å

PDB Description: structure of the dual enzyme ire1 reveals the basis for catalysis and regulation of non-conventional splicing

PDB Compounds: (A:) Serine/threonine-protein kinase/endoribonuclease IRE1

SCOPe Domain Sequences for d2rioa_:

Sequence, based on SEQRES records:

>d2rioa_ d.144.1.7 (A:) Endoribonuclease Ire1 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
nfeqslknlvvsekilgygssgtvvfqgsfqgrpvavkrmlidfcdialmeiklltesdd
hpnviryycsettdrflyialelcnlnlqdlvesknvsdenlklqkeynpisllrqiasg
vahlhslkiihrdlkpqnilvstssrftadqqtgaenlrilisdfglckkldsgqssfrt
nlnnpsgtsgwrapelleesnnlqtkrrltrsidifsmgcvfyyilskgkhpfgdkysre
sniirgifsldemkclhdrsliaeatdlisqmidhdplkrptamkvlrhplfwpkskkle
fllkvsdrleienrdppsallmkfdagsdfvipsgdwtvkfdktfmdnleryrkyhsskl
mdllralrnkyhhfmdlpediaelmgpvpdgfydyftkrfpnlligvymivkenlsddqi
lreflys

Sequence, based on observed residues (ATOM records):

>d2rioa_ d.144.1.7 (A:) Endoribonuclease Ire1 {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
nfeqslknlvvsekilgygssgtvvfqgsfqgrpvavkrmlidfcdialmeiklltesdd
hpnviryycsettdrflyialelcnlnlqdlveskynpisllrqiasgvahlhslkiihr
dlkpqnilvstssrftadqqtgaenlrilisdfglckkldstsgwrapelleesnnlqtk
rrltrsidifsmgcvfyyilskgkhpfgdkysresniirgifsldemkclhdrsliaeat
dlisqmidhdplkrptamkvlrhplfwpkskklefllkvsdrleienrdppsallmkfda
gsdfvipsgdwtvkfdktfmdrkyhssklmdllralrnkyhhfmdlpediaelmgpvpdg
fydyftkrfpnlligvymivkenlsddqilreflys

Timeline for d2rioa_:

• d2rioa_ first appeared in SCOPe 2.06
  
• d2rioa_ appears in SCOPe 2.07