SCOPe 2.08: Domain d1dnca2: 1dnc A:166-290

Lineage for d1dnca2 (1dnc A:166-290)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families)

5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (25 proteins)
   duplication: both domains have similar folds and functions
   most members of the family contain common C-terminal alpha+beta domain

6. Protein Glutathione reductase, middle domain [418943] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [419397] (23 PDB entries)

8. Domain d1dnca2: 1dnc A:166-290 [30444]
   Other proteins in same PDB: d1dnca1, d1dnca3
   complexed with fad, gsh, po4

Details for d1dnca2

PDB Entry: 1dnc, 1.7 Å

PDB Description: human glutathione reductase modified by diglutathione-dinitroso-iron

PDB Compounds: (A:) glutathione reductase

SCOPe Domain Sequences for d1dnca2:

Sequence; same for both SEQRES and ATOM records:

>d1dnca2 c.3.1.5 (A:166-290) Glutathione reductase, middle domain {Human (Homo sapiens) [TaxId: 9606]}
sqipgaslgitsdgffqleelpgrsvivgagyiavemagilsalgsktslmirhdkvlrs
fdsmistncteelenagvevlkfsqvkevkktlsglevsmvtavpgrlpvmtmipdvdcl
lwaig

Timeline for d1dnca2:

• d1dnca2 first appeared (with stable ids) in SCOP 1.55, called d1dnc_2
  
• d1dnca2 appears in SCOPe 2.07