SCOPe 2.08: Domain d2pqpb_: 2pqp B:

Lineage for d2pqpb_ (2pqp B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein Histone deacetylase 7, HDAC7 [159582] (1 species)
   HDAC7a

7. Species Human (Homo sapiens) [TaxId:9606] [159583] (9 PDB entries)
   Uniprot Q8WUI4 515-900

8. Domain d2pqpb_: 2pqp B: [304371]
   automated match to d3c10b_
   complexed with k, tsn, zn

Details for d2pqpb_

PDB Entry: 2pqp, 1.8 Å

PDB Description: Crystal structure of human HDAC7 in complex with Trichostatin A (TSA)

PDB Compounds: (B:) Histone deacetylase 7a

SCOPe Domain Sequences for d2pqpb_:

Sequence, based on SEQRES records:

>d2pqpb_ c.42.1.2 (B:) Histone deacetylase 7, HDAC7 {Human (Homo sapiens) [TaxId: 9606]}
lpfttgliydsvmlkhqcscgdnsrhpehagriqsiwsrlqerglrsqceclrgrkasle
elqsvhserhvllygtnplsrlkldngklagllaqrmfvmlpcggvgvdtdtiwnelhss
naarwaagsvtdlafkvasrelkngfavvrppghhadhstamgfcffnsvaiacrqlqqq
skaskilivdwdvhhgngtqqtfyqdpsvlyislhrhddgnffpgsgavdevgagsgegf
nvnvawaggldppmgdpeylaafrivvmpiarefspdlvlvsagfdaaeghpaplggyhv
sakcfgymtqqlmnlaggavvlalegghdltaicdaseacvaallgnrvdplseegwkqk
pnlnairsleavirvhskywgcmqrl

Sequence, based on observed residues (ATOM records):

>d2pqpb_ c.42.1.2 (B:) Histone deacetylase 7, HDAC7 {Human (Homo sapiens) [TaxId: 9606]}
lpfttgliydsvmlkhqcscgdnsrhpehagriqsiwsrlqerglrsqceclrgrkasle
elqsvhserhvllygtnplsvmlpcggvgvdtdtiwnelhssnaarwaagsvtdlafkva
srelkngfavvrppghhadhstamgfcffnsvaiacrqlqqqskaskilivdwdvhhgng
tqqtfyqdpsvlyislhrhddgnffpgsgavdevgagsgegfnvnvawaggldppmgdpe
ylaafrivvmpiarefspdlvlvsagfdaaeghpaplggyhvsakcfgymtqqlmnlagg
avvlalegghdltaicdaseacvaallgnrvdplseegwkqkpnlnairsleavirvhsk
ywgcmqrl

Timeline for d2pqpb_:

• d2pqpb_ first appeared in SCOPe 2.06
  
• d2pqpb_ appears in SCOPe 2.07