Lineage for d2p8kh_ (2p8k H:)

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2102557Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2102558Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2102904Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2103278Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)
  7. 2103281Species Leishmania major [TaxId:5664] [63926] (13 PDB entries)
    Uniprot Q01782
  8. 2103322Domain d2p8kh_: 2p8k H: [304338]
    automated match to d1e92b_
    complexed with dyp, nap

Details for d2p8kh_

PDB Entry: 2p8k (more details), 2.4 Å

PDB Description: Selective screening and design to identify inhibitors of Leishmania major pteridine reductase 1.
PDB Compounds: (H:) pteridine reductase 1

SCOPe Domain Sequences for d2p8kh_:

Sequence, based on SEQRES records: (download)

>d2p8kh_ c.2.1.2 (H:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapvsgadgsapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrnded
ghepcvgdreametatadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamt
nqpllgytiytmakgalegltrsaalelaplqirvngvgpglsvlvddmppavweghrsk
vplyqrdssaaevsdvviflcsskakyitgtcvkvdggysltra

Sequence, based on observed residues (ATOM records): (download)

>d2p8kh_ c.2.1.2 (H:) Dihydropteridin reductase (pteridine reductase) {Leishmania major [TaxId: 5664]}
tvpvalvtgaakrlgrsiaeglhaegyavclhyhrsaaeanalsatlnarrpnsaitvqa
dlsnvatapapvtlftrcaelvaacythwgrcdvlvnnassfyptpllrndgdreameta
tadlfgsnaiapyflikafahrvagtpakhrgtnysiinmvdamtnqpllgytiytmakg
alegltrsaalelaplqirvngvgpglsvlvddeghrskvplyqrdssaaevsdvviflc
sskakyitgtcvkvdggysltra

SCOPe Domain Coordinates for d2p8kh_:

Click to download the PDB-style file with coordinates for d2p8kh_.
(The format of our PDB-style files is described here.)

Timeline for d2p8kh_: