SCOPe 2.08: Domain d2j0cb_: 2j0c B:

Lineage for d2j0cb_ (2j0c B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.1: Cytochrome P450 [48265] (23 proteins)

6. Protein Mammalian cytochrome P450 3a4 [109958] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [109959] (7 PDB entries)
   Uniprot P08684

8. Domain d2j0cb_: 2j0c B: [304091]
   automated match to d1w0fa_
   complexed with hem, ktn

Details for d2j0cb_

PDB Entry: 2j0c, 2.8 Å

PDB Description: crystal structure of human p450 3a4 in complex with ketoconazole

PDB Compounds: (B:) cytochrome p450 3a4

SCOPe Domain Sequences for d2j0cb_:

Sequence, based on SEQRES records:

>d2j0cb_ a.104.1.1 (B:) Mammalian cytochrome P450 3a4 {Human (Homo sapiens) [TaxId: 9606]}
hglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpdm
iktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpii
aqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventkk
llrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledtqkhrv
dflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyelathpdvqq
klqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfip
kgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfal
mnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesr

Sequence, based on observed residues (ATOM records):

>d2j0cb_ a.104.1.1 (B:) Mammalian cytochrome P450 3a4 {Human (Homo sapiens) [TaxId: 9606]}
hglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpdm
iktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpii
aqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventkk
llrfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledvdflqlmi
dsqalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavlpnkapp
tydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsyalhrdp
kywtepekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirvlqnfsf
kpcketqiplklslggllqpekpvvlkvesr

Timeline for d2j0cb_:

• d2j0cb_ first appeared in SCOPe 2.06
  
• d2j0cb_ appears in SCOPe 2.07