SCOPe 2.08: Domain d2cl1a_: 2cl1 A:

Lineage for d2cl1a_ (2cl1 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Serine/threonine-protein kinase Nek2 [143893] (1 species)
   NIMA subfamily (NimA-related protein kinase 2)

7. Species Human (Homo sapiens) [TaxId:9606] [143894] (2 PDB entries)
   Uniprot P51955 3-271

8. Domain d2cl1a_: 2cl1 A: [303675]
   automated match to d2java1
   complexed with 5z5

Details for d2cl1a_

PDB Entry: 2cl1, 2.1 Å

PDB Description: human nek2 kinase with pyrrole-indolinone ligand

PDB Compounds: (A:) serine/threonine-protein kinase nek2

SCOPe Domain Sequences for d2cl1a_:

Sequence, based on SEQRES records:

>d2cl1a_ d.144.1.7 (A:) Serine/threonine-protein kinase Nek2 {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrsdgghtvlhrdlkpanvfldgkqnvklgdfglarilnhdtsfakafvgtpyy
mspeqmnrmsyneksdiwslgcllyelcalmppftafsqkelagkiregkfrripyrysd
elneiitrmlnlkdyhrpsveeilenplilehhhhhh

Sequence, based on observed residues (ATOM records):

>d2cl1a_ d.144.1.7 (A:) Serine/threonine-protein kinase Nek2 {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmtmlvsevnllrelkhpni
vryydriidtlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltlalkechrrs
hrdlkpanvfldgkqnvklgdfglarilgtpyymspeqmnrmsyneksdiwslgcllyel
calmppftafsqkelagkiregkfrripyrysdelneiitrmlnlkdyhrpsveeilenp
lilehhhhhh

Timeline for d2cl1a_:

• d2cl1a_ first appeared in SCOPe 2.06
  
• d2cl1a_ appears in SCOPe 2.07