Lineage for d1efkd1 (1efk D:280-573)

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  6. Protein Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
    includes C-terminal additional subdomains
  7. Species Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries)
  8. Domain d1efkd1: 1efk D:280-573 [30302]
    Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
    complexed with mak, mg, nad

Details for d1efkd1

PDB Entry: 1efk (more details), 2.6 Å

PDB Description: structure of human malic enzyme in complex with ketomalonate
PDB Compounds: (D:) malic enzyme

SCOPe Domain Sequences for d1efkd1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1efkd1 c.2.1.7 (D:280-573) Mitochondrial NAD(P)-dependent malic enzyme {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1efkd1 are not available.

Timeline for d1efkd1:

Domains from same chain:
(mouse over for more information)
Domains from other chains:
(mouse over for more information)
d1efka1, d1efka2, d1efkb1, d1efkb2, d1efkc1, d1efkc2