Lineage for d1efkc1 (1efk C:280-573)

  1. Root: SCOPe 2.07
  2. 2434694Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2449371Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2449372Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2453552Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
    extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site
  6. 2453716Protein Mitochondrial NAD(P)-dependent malic enzyme [51898] (3 species)
    includes C-terminal additional subdomains
  7. 2453734Species Human (Homo sapiens) [TaxId:9606] [51899] (10 PDB entries)
  8. 2453767Domain d1efkc1: 1efk C:280-573 [30301]
    Other proteins in same PDB: d1efka2, d1efkb2, d1efkc2, d1efkd2
    complexed with mak, mg, nad

Details for d1efkc1

PDB Entry: 1efk (more details), 2.6 Å

PDB Description: structure of human malic enzyme in complex with ketomalonate
PDB Compounds: (C:) malic enzyme

SCOPe Domain Sequences for d1efkc1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1efkc1 c.2.1.7 (C:280-573) Mitochondrial NAD(P)-dependent malic enzyme {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1efkc1:

Click to download the PDB-style file with coordinates for d1efkc1.
(The format of our PDB-style files is described here.)

Timeline for d1efkc1: