SCOP 1.65: Domain d1do8a1: 1do8 A:280-573

Lineage for d1do8a1 (1do8 A:280-573)

Root: SCOP 1.65
Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (10 proteins)
extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

Protein Mitochondrial NAD(P)-dependenent malic enzyme [51898] (3 species)
includes C-terminal additional subdomains
Species Human (Homo sapiens) [TaxId:9606] [51899] (7 PDB entries)
Domain d1do8a1: 1do8 A:280-573 [30289]
Other proteins in same PDB: d1do8a2, d1do8b2, d1do8c2, d1do8d2

Details for d1do8a1

PDB Entry: 1do8 (more details), 2.2 Å

PDB Description: crystal structure of a closed form of human mitochondrial nad(p)+- dependent malic enzyme

SCOP Domain Sequences for d1do8a1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1do8a1 c.2.1.7 (A:280-573) Mitochondrial NAD(P)-dependenent malic enzyme {Human (Homo sapiens)}
iqgtaavalagllaaqkviskpisehkilflgageaalgianlivmsmvenglseqeaqk
kiwmfdkygllvkgrkakidsyqepfthsapesipdtfedavnilkpstiigvagagrlf
tpdviramasinerpvifalsnptaqaectaeeaytltegrclfasgspfgpvkltdgrv
ftpgqgnnvyifpgvalavilcntrhisdsvfleaakaltsqltdeelaqgrlypplani
qevsiniaikvteylyankmafrypepedkakyvkertwrseydsllpdvyewp

SCOP Domain Coordinates for d1do8a1:

Click to download the PDB-style file with coordinates for d1do8a1.
(The format of our PDB-style files is described here.)

Timeline for d1do8a1: