SCOPe 2.07: Domain d1edza1: 1edz A:149-319

Lineage for d1edza1 (1edz A:149-319)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

6. Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species)
   the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51897] (2 PDB entries)

8. Domain d1edza1: 1edz A:149-319 [30287]
   Other proteins in same PDB: d1edza2

Details for d1edza1

PDB Entry: 1edz, 2.8 Å

PDB Description: structure of the nad-dependent 5,10-methylenetetrahydrofolate dehydrogenase from saccharomyces cerevisiae

PDB Compounds: (A:) 5,10-methylenetetrahydrofolate dehydrogenase

SCOPe Domain Sequences for d1edza1:

Sequence; same for both SEQRES and ATOM records:

>d1edza1 c.2.1.7 (A:149-319) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
pctplaivkileflkiynnllpegnrlygkkcivinrseivgrplaallandgatvysvd
vnniqkftrgeslklnkhhvedlgeysedllkkcsldsdvvitgvpsenykfpteyikeg
avcinfactknfsddvkekaslyvpmtgkvtiamllrnmlrlvrnvelske

Timeline for d1edza1:

• d1edza1 first appeared (with stable ids) in SCOP 1.55
  
• d1edza1 appears in SCOPe 2.06
  
• d1edza1 appears in the current release, SCOPe 2.08