SCOP 1.69: Domain d1dibb1: 1dib B:1127-1296

Lineage for d1dibb1 (1dib B:1127-1296)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (11 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

6. Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species)
   the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated

7. Species Human (Homo sapiens) [TaxId:9606] [51895] (4 PDB entries)

8. Domain d1dibb1: 1dib B:1127-1296 [30285]
   Other proteins in same PDB: d1diba2, d1dibb2

Details for d1dibb1

PDB Entry: 1dib, 2.7 Å

PDB Description: human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly345899

SCOP Domain Sequences for d1dibb1:

Sequence; same for both SEQRES and ATOM records:

>d1dibb1 c.2.1.7 (B:1127-1296) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Human (Homo sapiens)}
ltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapmhdlll
wnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyvpddkk
pngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

Timeline for d1dibb1:

• d1dibb1 first appeared (with stable ids) in SCOP 1.55
  
• d1dibb1 appears in SCOP 1.67
  
• d1dibb1 appears in SCOP 1.71
  
• d1dibb1 appears in the current release, SCOPe 2.08