SCOPe 2.04: Domain d1diga1: 1dig A:127-296

Lineage for d1diga1 (1dig A:127-296)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (12 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

6. Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species)
   the two-domain organization is similar to that of aminoacid dehydrogenases, but both domains are truncated

7. Species Human (Homo sapiens) [TaxId:9606] [51895] (4 PDB entries)

8. Domain d1diga1: 1dig A:127-296 [30282]
   Other proteins in same PDB: d1diga2, d1digb2
   complexed with act, l37, nap

Details for d1diga1

PDB Entry: 1dig, 2.2 Å

PDB Description: human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly374571

PDB Compounds: (A:) methylenetetrahydrofolate dehydrogenase / cyclohydrolase

SCOPe Domain Sequences for d1diga1:

Sequence, based on SEQRES records:

>d1diga1 c.2.1.7 (A:127-296) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Human (Homo sapiens) [TaxId: 9606]}
ltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapmhdlll
wnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyvpddkk
pngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

Sequence, based on observed residues (ATOM records):

>d1diga1 c.2.1.7 (A:127-296) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Human (Homo sapiens) [TaxId: 9606]}
ltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapmhdlll
wnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginykvvgdv
aydeakerasfitpvpggvgpmtvamlmqstvesakrfle

Timeline for d1diga1:

• d1diga1 first appeared (with stable ids) in SCOP 1.55
  
• d1diga1 appears in SCOPe 2.03
  
• d1diga1 appears in SCOPe 2.05
  
• d1diga1 appears in the current release, SCOPe 2.08