SCOP 1.55: Domain d1a4ia1: 1a4i A:127-296

Lineage for d1a4ia1 (1a4i A:127-296)

1. Root: SCOP 1.55

2. Class c: Alpha and beta proteins (a/b) [51349] (97 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (8 families)

5. Family c.2.1.7: Amino-acid dehydrogenase-like, C-terminal domain [51883] (5 proteins)

6. Protein Methylenetetrahydrofolate dehydrogenase/cyclohydrolase [51894] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51895] (4 PDB entries)

8. Domain d1a4ia1: 1a4i A:127-296 [30278]
   Other proteins in same PDB: d1a4ia2, d1a4ib2

Details for d1a4ia1

PDB Entry: 1a4i, 1.5 Å

PDB Description: human tetrahydrofolate dehydrogenase / cyclohydrolase

SCOP Domain Sequences for d1a4ia1:

Sequence, based on SEQRES records:

>d1a4ia1 c.2.1.7 (A:127-296) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Human (Homo sapiens)}
ltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapmhdlll
wnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyvpddkk
pngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

Sequence, based on observed residues (ATOM records):

>d1a4ia1 c.2.1.7 (A:127-296) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Human (Homo sapiens)}
ltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapmhdlll
wnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginykvvgdv
aydeakerasfitpvpggvgpmtvamlmqstvesakrfle

Timeline for d1a4ia1:

• d1a4ia1 appears in SCOP 1.57
  
• d1a4ia1 appears in the current release, SCOPe 2.08