SCOPe 2.06: Domain d1ngvb_: 1ngv B:

Lineage for d1ngvb_ (1ngv B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 proteins)
   the common fold is elaborated with additional (sub)domains

6. Protein automated matches [310845] (1 species)
   not a true protein

7. Species Homo sapiens [311164] (1 PDB entry)

8. Domain d1ngvb_: 1ngv B: [302767]
   Other proteins in same PDB: d1ngva_, d1ngvc_
   automated match to d3dblb_
   complexed with zn

Details for d1ngvb_

PDB Entry: 1ngv, 2.6 Å

PDB Description: Insights into the ubiquitin transfer cascade from the structure of the E1 for NEDD8.

PDB Compounds: (B:) uba3

SCOPe Domain Sequences for d1ngvb_:

Sequence, based on SEQRES records:

>d1ngvb_ c.111.1.2 (B:) automated matches {Homo sapiens}
dwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsg
frqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfn
dtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarv
ilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldg
ddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkia
tsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqfspsaklqevldyltns
aslqmkspaitatlegknrtlylqsvtsieertrpnlsktlkelglvdgqelavadvttp
qtvlfklhft

Sequence, based on observed residues (ATOM records):

>d1ngvb_ c.111.1.2 (B:) automated matches {Homo sapiens}
dwegrwnhvkkflersgpfthpdfepsteslqflldtckvlvigagglgcellknlalsg
frqihvidmdtidvsnlnrqflfrpkdigrpkaevaaeflndrvpncnvvphfnkiqdfn
dtfyrqfhiivcgldsiiarrwingmlisllnyedgvldpssivplidggtegfkgnarv
ilpgmtaciectlelyppqvnfpmctiasmprlpehcieyvrmlqwpkeqpfgegvpldg
ddpehiqwifqkslerasqynirgvtyrltqgvvkriipavastnaviaavcatevfkia
tsayiplnnylvfndvdglytytfeaerkencpacsqlpqniqlqevldyltnsaslqmk
spaitatrtlylqseertrpnladvttpqtvlfklhft

Timeline for d1ngvb_:

• d1ngvb_ is new in SCOPe 2.06-stable
  
• d1ngvb_ appears in SCOPe 2.07
  
• d1ngvb_ appears in the current release, SCOPe 2.08