SCOPe 2.08: Domain d1liyb4: 1liy B:57-159,B:262-439

Lineage for d1liyb4 (1liy B:57-159,B:262-439)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (8 families)

5. Family c.1.12.1: Pyruvate kinase [51622] (1 protein)

6. Protein Pyruvate kinase, N-terminal domain [51623] (6 species)
   this domain is interrupted by an all-beta domain
   C-terminal domain is alpha/beta

7. Species Human (Homo sapiens) [TaxId:9606] [82273] (8 PDB entries)

8. Domain d1liyb4: 1liy B:57-159,B:262-439 [302701]
   Other proteins in same PDB: d1liya5, d1liya6, d1liyb5, d1liyc5, d1liyc6, d1liyd5, d1liyd6
   automated match to d2vggb2
   complexed with fbp, k, mn, pga; mutant

Details for d1liyb4

PDB Entry: 1liy, 2.74 Å

PDB Description: Human erythrocyte pyruvate kinase: Arg479His mutant

PDB Compounds: (B:) Pyruvate kinase, isozymes R/L

SCOPe Domain Sequences for d1liyb4:

Sequence, based on SEQRES records:

>d1liyb4 c.1.12.1 (B:57-159,B:262-439) Pyruvate kinase, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgXpglseqdvrdlrfgve
hgvdivfasfvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvar
gdlgieipaekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavld
gadcimlsgetakgnfpveavkmqhaiareaeaavyhrqlfe

Sequence, based on observed residues (ATOM records):

>d1liyb4 c.1.12.1 (B:57-159,B:262-439) Pyruvate kinase, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
qqqqlpadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniarlnf
shgsheyhaesianvreavesfagsplsyrpvaialdtkgXpglseqdvrdlrfgvehgv
divfasfvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvargdl
gieipaekvflaqkmmigrcnlagkpvvcatqmlesmitkprptraetsdvanavldgad
cimlsgetakgnfpveavkmqhaiareaeaavyhrqlfe

Timeline for d1liyb4:

• d1liyb4 first appeared in SCOPe 2.06
  
• d1liyb4 appears in SCOPe 2.07