SCOPe 2.06: Domain d1liwb4: 1liw B:57-159,B:262-439

Lineage for d1liwb4 (1liw B:57-159,B:262-439)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.12: Phosphoenolpyruvate/pyruvate domain [51621] (8 families)

5. Family c.1.12.1: Pyruvate kinase [51622] (1 protein)

6. Protein Pyruvate kinase, N-terminal domain [51623] (6 species)
   this domain is interrupted by an all-beta domain
   C-terminal domain is alpha/beta

7. Species Human (Homo sapiens) [TaxId:9606] [82273] (8 PDB entries)

8. Domain d1liwb4: 1liw B:57-159,B:262-439 [302688]
   Other proteins in same PDB: d1liwa5, d1liwa6, d1liwb5, d1liwc5, d1liwc6
   automated match to d2vgfa2
   complexed with fbp, k, mn, pga; mutant

Details for d1liwb4

PDB Entry: 1liw, 2.75 Å

PDB Description: Human erythrocyte pyruvate kinase: Thr384Met mutant

PDB Compounds: (B:) Pyruvate kinase, isozymes R/L

SCOPe Domain Sequences for d1liwb4:

Sequence; same for both SEQRES and ATOM records:

>d1liwb4 c.1.12.1 (B:57-159,B:262-439) Pyruvate kinase, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
qqqqlpaamadtflehlclldidsepvaarstsiiatigpasrsverlkemikagmniar
lnfshgsheyhaesianvreavesfagsplsyrpvaialdtkgXpglseqdvrdlrfgve
hgvdivfasfvrkasdvaavraalgpeghgikiiskienhegvkrfdeilevsdgimvar
gdlgieipaekvflaqkmmigrcnlagkpvvcatqmlesmitkprpmraetsdvanavld
gadcimlsgetakgnfpveavkmqhaiareaeaavyhrqlfe

Timeline for d1liwb4:

• d1liwb4 is new in SCOPe 2.06-stable
  
• d1liwb4 appears in SCOPe 2.07
  
• d1liwb4 appears in the current release, SCOPe 2.08