SCOPe 2.08: Domain d1ceta1: 1cet A:18-163

Lineage for d1ceta1 (1cet A:18-163)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.5: LDH N-terminal domain-like [51848] (9 proteins)

6. Protein Lactate dehydrogenase [51859] (19 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51863] (14 PDB entries)

8. Domain d1ceta1: 1cet A:18-163 [30164]
   Other proteins in same PDB: d1ceta2
   complexed with clq

Details for d1ceta1

PDB Entry: 1cet, 2.05 Å

PDB Description: chloroquine binds in the cofactor binding site of plasmodium falciparum lactate dehydrogenase.

PDB Compounds: (A:) protein (l-lactate dehydrogenase)

SCOPe Domain Sequences for d1ceta1:

Sequence, based on SEQRES records:

>d1ceta1 c.2.1.5 (A:18-163) Lactate dehydrogenase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
apkakivlvgsgmiggvmatlivqknlgdvvlfdivknmphgkaldtshtnvmaysnckv
sgsntyddlagsdvvivtagftkapgksdkewnrldllplnnkimieigghikkncpnaf
iivvtnpvdvmvqllhqhsgvpknkiigl

Sequence, based on observed residues (ATOM records):

>d1ceta1 c.2.1.5 (A:18-163) Lactate dehydrogenase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
apkakivlvgsgmiggvmatlivqknlgdvvlfdivknmphgkaldtshtnvmaysnckv
sgsntyddlagsdvvivtagftnrldllplnnkimieigghikkncpnafiivvtnpvdv
mvqllhqhsgvpknkiigl

Timeline for d1ceta1:

• d1ceta1 first appeared (with stable ids) in SCOP 1.55
  
• d1ceta1 appears in SCOPe 2.07