SCOPe 2.06: Domain d1fdvd_: 1fdv D:

Lineage for d1fdvd_ (1fdv D:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51773] (22 PDB entries)
   Uniprot P14061

8. Domain d1fdvd_: 1fdv D: [29855]
   complexed with nad, so4; mutant

Details for d1fdvd_

PDB Entry: 1fdv, 3.1 Å

PDB Description: human 17-beta-hydroxysteroid-dehydrogenase type 1 mutant h221l complexed with nad+

PDB Compounds: (D:) 17-beta-hydroxysteroid dehydrogenase

SCOPe Domain Sequences for d1fdvd_:

Sequence, based on SEQRES records:

>d1fdvd_ c.2.1.2 (D:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylalskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgd

Sequence, based on observed residues (ATOM records):

>d1fdvd_ c.2.1.2 (D:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtevldrtdihtfhrfyqylalskqvfreaaqnpeevaevfltalrapkptl
ryftterflpllrmrlddpsgsnyvtamhrevfgd

Timeline for d1fdvd_:

• d1fdvd_ first appeared (with stable ids) in SCOP 1.55
  
• d1fdvd_ appears in SCOPe 2.05
  
• d1fdvd_ appears in SCOPe 2.07
  
• d1fdvd_ appears in the current release, SCOPe 2.08