Lineage for d1a27a_ (1a27 A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2091485Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  7. 2091486Species Human (Homo sapiens) [TaxId:9606] [51773] (22 PDB entries)
    Uniprot P14061
  8. 2091495Domain d1a27a_: 1a27 A: [29839]
    complexed with est, nap; mutant

Details for d1a27a_

PDB Entry: 1a27 (more details), 1.9 Å

PDB Description: human 17-beta-hydroxysteroid-dehydrogenase type 1 c-terminal deletion mutant complexed with estradiol and nadp+
PDB Compounds: (A:) 17-beta-hydroxysteroid-dehydrogenase

SCOPe Domain Sequences for d1a27a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1a27a_ c.2.1.2 (A:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1a27a_:

Click to download the PDB-style file with coordinates for d1a27a_.
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Timeline for d1a27a_: