SCOP 1.73: Domain d1dhra_: 1dhr A:

Lineage for d1dhra_ (1dhr A:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Dihydropteridin reductase (pteridine reductase) [51769] (6 species)

7. Species Rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)

8. Domain d1dhra_: 1dhr A: [29832]
   complexed with nad

Details for d1dhra_

PDB Entry: 1dhr, 2.3 Å

PDB Description: crystal structure of rat liver dihydropteridine reductase

PDB Compounds: (A:) Dihydropteridine reductase

SCOP Domain Sequences for d1dhra_:

Sequence; same for both SEQRES and ATOM records:

>d1dhra_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Rat (Rattus norvegicus) [TaxId: 10116]}
earrvlvyggrgalgsrcvqafrarnwwvasidvveneeasasvivkmtdsfteqadqvt
aevgkllgdqkvdailcvaggwaggnakskslfkncdlmwkqsiwtstisshlatkhlke
gglltlagakaaldgtpgmigygmakgavhqlcqslagknsgmpsgaaaiavlpvtldtp
mnrksmpeadfsswtpleflvetfhdwitgnkrpnsgsliqvvttdgkteltpayf

Timeline for d1dhra_:

• d1dhra_ first appeared (with stable ids) in SCOP 1.55, called d1dhr__
  
• d1dhra_ was called d1dhr__ in SCOP 1.71
  
• d1dhra_ appears in SCOP 1.75
  
• d1dhra_ appears in the current release, SCOPe 2.08