SCOP 1.75: Domain d1agnd2: 1agn D:163-338

Lineage for d1agnd2 (1agn D:163-338)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (16 proteins)
   N-terminal all-beta domain defines family

6. Protein Alcohol dehydrogenase [51737] (9 species)

7. Species Human (Homo sapiens), different isozymes [TaxId:9606] [51739] (24 PDB entries)
   Uniprot P00326
   Uniprot P00325
   Uniprot P07327
   Uniprot P00326 ! Uniprot P00325 ! Uniprot P07327

8. Domain d1agnd2: 1agn D:163-338 [29756]
   Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
   sigma isozyme
   complexed with act, nad, zn

Details for d1agnd2

PDB Entry: 1agn, 3 Å

PDB Description: x-ray structure of human sigma alcohol dehydrogenase

PDB Compounds: (D:) human sigma alcohol dehydrogenase

SCOP Domain Sequences for d1agnd2:

Sequence; same for both SEQRES and ATOM records:

>d1agnd2 c.2.1.1 (D:163-338) Alcohol dehydrogenase {Human (Homo sapiens), different isozymes [TaxId: 9606]}
aappekvcligcgfstgygaavktgkvkpgstcvvfglggvglsvimgcksagasriigi
dlnkdkfekamavgatecispkdstkpisevlsemtgnnvgytfevighletmidalasc
hmnygtsvvvgvppsakmltydpmllftgrtwkgcvfgglksrddvpklvteflak

Timeline for d1agnd2:

• d1agnd2 first appeared (with stable ids) in SCOP 1.55
  
• d1agnd2 appears in SCOP 1.73
  
• d1agnd2 appears in SCOPe 2.01
  
• d1agnd2 appears in the current release, SCOPe 2.08