SCOPe 2.06: Domain d1a72a2: 1a72 A:164-339

Lineage for d1a72a2 (1a72 A:164-339)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain [51736] (17 proteins)
   N-terminal all-beta domain defines family

6. Protein Alcohol dehydrogenase [51737] (9 species)

7. Species Horse (Equus caballus) [TaxId:9796] [51738] (46 PDB entries)
   Uniprot P00327

8. Domain d1a72a2: 1a72 A:164-339 [29715]
   Other proteins in same PDB: d1a72a1
   complexed with pad, zn; mutant

Details for d1a72a2

PDB Entry: 1a72, 2.6 Å

PDB Description: an active-site double mutant (phe93->trp, val203->ala) of horse liver alcohol dehydrogenase in complex with the isosteric nad analog cpad

PDB Compounds: (A:) horse liver alcohol dehydrogenase

SCOPe Domain Sequences for d1a72a2:

Sequence; same for both SEQRES and ATOM records:

>d1a72a2 c.2.1.1 (A:164-339) Alcohol dehydrogenase {Horse (Equus caballus) [TaxId: 9796]}
splekvcligcgfstgygsavkvakvtqgstcavfglggaglsvimgckaagaariigvd
inkdkfakakevgatecvnpqdykkpiqevltemsnggvdfsfevigrldtmvtalsccq
eaygvsvivgvppdsqnlsmnpmlllsgrtwkgaifggfkskdsvpklvadfmakk

Timeline for d1a72a2:

• d1a72a2 first appeared (with stable ids) in SCOP 1.55, called d1a72_2
  
• d1a72a2 appears in SCOPe 2.05
  
• d1a72a2 appears in SCOPe 2.07
  
• d1a72a2 appears in the current release, SCOPe 2.08