SCOPe 2.08: Domain d4c27b_: 4c27 B:

Lineage for d4c27b_ (4c27 B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (99 species)
   not a true protein

7. Species Trypanosoma cruzi [TaxId:5693] [196511] (20 PDB entries)

8. Domain d4c27b_: 4c27 B: [296765]
   automated match to d3khma_
   complexed with 26n, cl, edo, hem

Details for d4c27b_

PDB Entry: 4c27, 1.95 Å

PDB Description: crystal structure of trypanosoma cruzi cyp51 bound to the inhibitor (r)-n-(3-(1h-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-2- fluoro-4-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)benzamide

PDB Compounds: (B:) Sterol 14-alpha demethylase

SCOPe Domain Sequences for d4c27b_:

Sequence, based on SEQRES records:

>d4c27b_ a.104.1.0 (B:) automated matches {Trypanosoma cruzi [TaxId: 5693]}
tdppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrf
fsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhe
vrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmessli
paavfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkav
yrdgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaq
lnydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshh
deeafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllr
devpdpdyhtmvvgptlnqclvkytrkkk

Sequence, based on observed residues (ATOM records):

>d4c27b_ a.104.1.0 (B:) automated matches {Trypanosoma cruzi [TaxId: 5693]}
tdppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrf
fsprneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhe
vrkfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmessli
paavfmpwllrlplpqsarcrearaelqkilgeiivarekeetsdllggllkavyrdgtr
mslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnv
mdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafp
nprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdp
dyhtmvvgptlnqclvkytrkkk

Timeline for d4c27b_:

• d4c27b_ first appeared in SCOPe 2.06
  
• d4c27b_ appears in SCOPe 2.07