SCOPe 2.08: Domain d3u88b2: 3u88 B:231-582

Lineage for d3u88b2 (3u88 B:231-582)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.8: TPR-like [48452] (11 families)

5. Family a.118.8.1: Tetratricopeptide repeat (TPR) [48453] (21 proteins)
   this is a repeat family; one repeat unit is 1zb1 A:166-231 found in domain

6. Protein Menin C-terminal domain [310725] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [310974] (33 PDB entries)

8. Domain d3u88b2: 3u88 B:231-582 [295680]
   Other proteins in same PDB: d3u88a1, d3u88b1, d3u88c_, d3u88d_
   automated match to d3u85a2
   complexed with 0br, chd, ggb, glv, so4
   has additional insertions and/or extensions that are not grouped together

Details for d3u88b2

PDB Entry: 3u88, 3 Å

PDB Description: crystal structure of human menin in complex with mll1 and ledgf

PDB Compounds: (B:) Menin

SCOPe Domain Sequences for d3u88b2:

Sequence, based on SEQRES records:

>d3u88b2 a.118.8.1 (B:231-582) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleageerpgeqsqgtqsqgsalqdpecf
ahllrfydgickweegsptpvlhvgwatflvqslgrfegqvrqkvrivsgtvagtargpe
ggstaqvpaptaspppegpvltfqsekmkgmkellvatkinssaiklqltaq

Sequence, based on observed residues (ATOM records):

>d3u88b2 a.118.8.1 (B:231-582) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagqgsalqdpecfahllrfydgickw
eegsptpvlhvgwatflvqslgrfegqvrqkvrivsgpppegpvltfqsekmkgmkellv
atkinssaiklqltaq

Timeline for d3u88b2:

• d3u88b2 first appeared in SCOPe 2.06
  
• d3u88b2 appears in SCOPe 2.07