SCOP 1.73: Domain d1cpua2: 1cpu A:1-403

Lineage for d1cpua2 (1cpu A:1-403)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (14 families)

5. Family c.1.8.1: Amylase, catalytic domain [51446] (24 proteins)
   members of the family may contain various insert subdomains
   in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain

6. Protein Animal alpha-amylase [51458] (3 species)
   contains Ca2+-binding subdomain, residues 100-170

7. Species Human (Homo sapiens) [TaxId:9606] [51460] (33 PDB entries)

8. Domain d1cpua2: 1cpu A:1-403 [28758]
   Other proteins in same PDB: d1cpua1
   complexed with agl, ca, cl, glc, hmc, nag

Details for d1cpua2

PDB Entry: 1cpu, 2 Å

PDB Description: subsite mapping of the active site of human pancreatic alpha-amylase using substrates, the pharmacological inhibitor acarbose, and an active site variant

PDB Compounds: (A:) protein (alpha-amylase)

SCOP Domain Sequences for d1cpua2:

Sequence; same for both SEQRES and ATOM records:

>d1cpua2 c.1.8.1 (A:1-403) Animal alpha-amylase {Human (Homo sapiens) [TaxId: 9606]}
eyspntqqgrtsivhlfewrwvdialecerylapkgfggvqvsppnenvaiynpfrpwwe
ryqpvsyklctrsgnedefrnmvtrcnnvgvriyvdavinhmcgnavsagtsstcgsyfn
pgsrdfpavpysgwdfndgkcktgsgdienyndatqvrdcrltglldlalekdyvrskia
eymnhlidigvagfrldaskhmwpgdikaildklhnlnsnwfpagskpfiyqevidlgge
pikssdyfgngrvtefkygaklgtvirkwngekmsylknwgegwgfvpsdralvfvdnhd
nqrghgaggasiltfwdarlykmavgfmlahpygftrvmssyrwprqfqngndvndwvgp
pnnngvikevtinpdttcgndwvcehrwrqirnmvifrnvvdg

Timeline for d1cpua2:

• d1cpua2 first appeared (with stable ids) in SCOP 1.55
  
• d1cpua2 appears in SCOP 1.71
  
• d1cpua2 appears in SCOP 1.75
  
• d1cpua2 appears in the current release, SCOPe 2.08