SCOPe 2.06: Domain d2f8tb3: 2f8t B:315-487

Lineage for d2f8tb3 (2f8t B:315-487)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.44: Phosphotyrosine protein phosphatases I-like [52787] (3 superfamilies)
   3 layers: a/b/a; parallel beta-sheet of 4 strands, order 2134

4. Superfamily c.44.3: PIWI domain N-terminal-like [310581] (2 families)

5. Family c.44.3.1: PIWI domain N-terminal [310609] (4 proteins)
   PubMed 15565169 notes that both halves of PIWI are usually a single evolutionary unit; however, fragments have been characterized separately. The C-terminal half is (c.55.3.10)

6. Protein Argonaute homologue Aq_1447 [310684] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [310901] (4 PDB entries)

8. Domain d2f8tb3: 2f8t B:315-487 [286910]
   Other proteins in same PDB: d2f8ta1, d2f8ta4, d2f8tb1, d2f8tb4
   protein/RNA complex

Details for d2f8tb3

PDB Entry: 2f8t, 3.1 Å

PDB Description: Crystal structure of Aa-Ago with externally-bound siRNA

PDB Compounds: (B:) Argonaute protein

SCOPe Domain Sequences for d2f8tb3:

Sequence; same for both SEQRES and ATOM records:

>d2f8tb3 c.44.3.1 (B:315-487) Argonaute homologue Aq_1447 {Aquifex aeolicus [TaxId: 63363]}
klnfkdtvldakgkntkvitnlrkflelcrpfvkkdvlsveiisvsvykklewrkeeflk
elinflknkgiklkikgkslilaqtreeakeklipvinkikdvdlvivfleeypkvdpyk
sfllydfvkrellkkmipsqvilnrtlknenlkfvllnvaeqvlaktgnipyk

Timeline for d2f8tb3:

• d2f8tb3 is new in SCOPe 2.06-stable
  
• d2f8tb3 appears in SCOPe 2.07
  
• d2f8tb3 appears in the current release, SCOPe 2.08