Lineage for d2acua_ (2acu A:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2080913Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families) (S)
  5. 2080914Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 protein domains)
    Common fold covers whole protein structure
  6. 2080974Protein Aldose reductase (aldehyde reductase) [51436] (2 species)
  7. 2080975Species Human (Homo sapiens) [TaxId:9606] [51437] (133 PDB entries)
    Uniprot P15121
  8. 2081072Domain d2acua_: 2acu A: [28676]
    complexed with cit, nap; mutant

Details for d2acua_

PDB Entry: 2acu (more details), 1.76 Å

PDB Description: tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and the crystal structure of the y48h mutant enzyme
PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d2acua_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2acua_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2acua_:

Click to download the PDB-style file with coordinates for d2acua_.
(The format of our PDB-style files is described here.)

Timeline for d2acua_: