SCOPe 2.01: Domain d1b3oa1: 1b3o A:10-109,A:232-499

Lineage for d1b3oa1 (1b3o A:10-109,A:232-499)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (1 family)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

7. Species Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)

8. Domain d1b3oa1: 1b3o A:10-109,A:232-499 [28640]
   Other proteins in same PDB: d1b3ob4
   contains two CBS domains inserted into the common fold, residues 112-231
   complexed with cpr, sae, unx

Details for d1b3oa1

PDB Entry: 1b3o, 2.9 Å

PDB Description: ternary complex of human type-ii inosine monophosphate dehydrogenase with 6-cl-imp and selenazole adenine dinucleotide

PDB Compounds: (A:) protein (inosine monophosphate dehydrogenase 2)

SCOPe Domain Sequences for d1b3oa1:

Sequence, based on SEQRES records:

>d1b3oa1 c.1.5.1 (A:10-109,A:232-499) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkXdyplaskdakkqllcgaai
gtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaaqa
knlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiqnv
ghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamdkhlssqnry
fseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgelkf
ekrtssaqv

Sequence, based on observed residues (ATOM records):

>d1b3oa1 c.1.5.1 (A:10-109,A:232-499) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkXdyplaskdakkqllcgaai
gtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaaqa
knlidagvdalrvgmgsrpqatavykvseyarrfgvpviadggiqnvghiakalalgast
vmmgsllaatteapgeydkgsihkfvpyliagiqhscqdigaksltqvrammysgelkfe
krtssaqv

Timeline for d1b3oa1:

• d1b3oa1 first appeared (with stable ids) in SCOP 1.55
  
• d1b3oa1 appears in SCOP 1.75
  
• d1b3oa1 appears in SCOPe 2.02
  
• d1b3oa1 appears in the current release, SCOPe 2.08