SCOPe 2.08: Domain d1a5sa_: 1a5s A:

Lineage for d1a5sa_ (1a5s A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (7 families)

5. Family c.1.2.4: Tryptophan biosynthesis enzymes [51381] (4 proteins)

6. Protein Trp synthase alpha-subunit [51388] (9 species)

7. Species Salmonella typhimurium [TaxId:90371] [51389] (72 PDB entries)

8. Domain d1a5sa_: 1a5s A: [28581]
   Other proteins in same PDB: d1a5sb_
   complexed with fip, na, plp, ser

Details for d1a5sa_

PDB Entry: 1a5s, 2.3 Å

PDB Description: crystal structure of wild-type tryptophan synthase complexed with 5-fluoroindole propanol phosphate and l-ser bound as amino acrylate to the beta site

PDB Compounds: (A:) tryptophan synthase (alpha chain)

SCOPe Domain Sequences for d1a5sa_:

Sequence, based on SEQRES records:

>d1a5sa_ c.1.2.4 (A:) Trp synthase alpha-subunit {Salmonella typhimurium [TaxId: 90371]}
eryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdpladg
ptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceqv
gvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrsg
vtgaenrgalplhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivkii
eknlaspkqmlaelrsfvsamkaasr

Sequence, based on observed residues (ATOM records):

>d1a5sa_ c.1.2.4 (A:) Trp synthase alpha-subunit {Salmonella typhimurium [TaxId: 90371]}
eryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdpladg
ptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceqv
gvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrsg
vtgaenlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivkiieknlaspk
qmlaelrsfvsamkaasr

Timeline for d1a5sa_:

• d1a5sa_ first appeared (with stable ids) in SCOP 1.55
  
• d1a5sa_ appears in SCOPe 2.07