SCOPe 2.06: Domain d2tysa_: 2tys A:

Lineage for d2tysa_ (2tys A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (7 families)

5. Family c.1.2.4: Tryptophan biosynthesis enzymes [51381] (4 proteins)

6. Protein Trp synthase alpha-subunit [51388] (8 species)

7. Species Salmonella typhimurium [TaxId:90371] [51389] (46 PDB entries)

8. Domain d2tysa_: 2tys A: [28572]
   Other proteins in same PDB: d2tysb_
   complexed with na, plt; mutant

Details for d2tysa_

PDB Entry: 2tys, 1.9 Å

PDB Description: crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes

PDB Compounds: (A:) tryptophan synthase

SCOPe Domain Sequences for d2tysa_:

Sequence, based on SEQRES records:

>d2tysa_ c.1.2.4 (A:) Trp synthase alpha-subunit {Salmonella typhimurium [TaxId: 90371]}
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllsrs
gvtgaenrgalplhhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivki
ieknlaspkqmlaelrsfvsamkaasra

Sequence, based on observed residues (ATOM records):

>d2tysa_ c.1.2.4 (A:) Trp synthase alpha-subunit {Salmonella typhimurium [TaxId: 90371]}
meryenlfaqlndrregafvpfvtlgdpgieqslkiidtlidagadalelgvpfsdplad
gptiqnanlrafaagvtpaqcfemlalirekhptipigllmyanlvfnngidafyarceq
vgvdsvlvadvpveesapfrqaalrhniapificppnadddllrqvasygrgytyllspl
hhlieklkeyhaapalqgfgisspeqvsaavragaagaisgsaivkiieknlaspkqmla
elrsfvsamkaasra

Timeline for d2tysa_:

• d2tysa_ first appeared (with stable ids) in SCOP 1.55
  
• d2tysa_ appears in SCOPe 2.05
  
• d2tysa_ appears in SCOPe 2.07
  
• d2tysa_ appears in the current release, SCOPe 2.08